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Introduction: Diabetes is one of the major causes of mortality worldwide. One of the complications of this disorder is hypertension. Today besides the routine medication in oxidative diseases such as diabetes and hypertension, antioxidant supplementation is used. One of the antioxidants used in these diseases is CoQ10. The aim of this study is to find out Methods: This is a double blind randomized controlled clinical trial which was held on 70 type 2 diabetic patients in Yazd Diabetes Research Center in 2011.The diabetic patients were randomly divided into two groups, CoQ10 and placebo. The Two groups took two capsules containing 100mg CoQ10 or placebo every day for 12 weeks. Systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arteriole pressure (MAP) was measured at the beginning and at the end of the intervention. Results: sixty two patients completed the study. The mean SBP,DBP and MAP of the Q10 group decreased in comparison with the control group after intervention. The mean of SBP decreased about of 12.65 mmHg in CoQ10 group compared to baseline. The mean of decline of DBP and MAP were 11.37 and 11.8 mmHG, respectively. Conclusion:This study revealed that CoQ10 supplementation significantly decreases the blood pressure in type 2 diabetes. Regarding to the results of this study and other reports, supplementation with CoQ10 can be recommended for diabetic patients especially in hypertension ones.

Keywords: Diabetes Mellitus, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arteriole Pressure, CoQ10

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