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Khademvsameni V, Ebrahimi F, Ahmadinia H, Tabatabaei S Z. Evaluating the Prevalence of Congenital Anomalies in Neonatal Live Births in Rafsanjan. TB 2023; 22 (2) :74-84
URL: http://tbj.ssu.ac.ir/article-1-3345-en.html
URL: http://tbj.ssu.ac.ir/article-1-3345-en.html
RUMS , seyedzia2003@yahoo.com
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Evaluating the Prevalence of Congenital Anomalies in Neonatal Live Births in Rafsanjan
Vahide Khadem Sameni (MPH)1, Fatemeh Ebrahimi (M.Sc.)2, Hassan Ahmadinia(Ph.D.)3, Seyed Zia Tabatabei (Ph.D.)4
1.MPH, Health Care Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2.MSc, Health Care Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
3.Assistant Professor, Department of Social Medicine, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
4.Corresponding Author : Assistant Professor, Department of Social Medicine, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Abstract
Introduction: Congenital anomalies are one of the important causes of disability and infant mortality. These abnormalities occur during egg fertilization or embryonic development, which can be detected by laboratory methods. The aim of this study is to investigate the prevalence of congenital anomalies in Rafsanjan City.
Methods: This cross-sectional study was performed on 4868 infants born in Rafsanjan city in 2018. Data collection tool was a questionnaire including information about mothers and infants. The questionnaire was completed using health records available in health centers of Rafsanjan city. Data were analyzed using SPSS 20 and independent t-test and Chi-square.
Results: The results showed that the overall prevalence of congenital anomalies in Rafsanjan was 5/38 per 1000 live births. Out of 4868 pregnant women, 474 (9/7%), had abortions or stillbirths before the second trimester, and 12 (0/2%) had therapeutic abortions. After analyzing these anomalies, three cases of Down syndrome (trisomy 21), three cases of Edward syndrome (trisomy 18), one case of aneuploidy, and two cases of microcephaly were found, and the rest had one of the structural abnormalities..
Conclusion: The results of this study indicated a high rate of congenital anomalies in Rafsanjan. Therefore, further studies are recommended to better understand the causes and prevent these anomalies.
Keywords: Congenital Abnormalities, Prevalence, Pregnant Women
References
1.Moezzi M, Malekpour A, pourheidar B, Mohammadkhani S. Evaluating Frequency and Risk Factors of Congenital Anomalies in Under 15 Disabled Children, Registered in Shahrekord Welfare Organization-2018. Iranian Journal of Pediatric Nursing (JPEN). 2020(6);4:47-58
2.Hashemipour M, Samei P, Kelishadi R, Hovsepian S, Hani Tabaei Zavareh N. A Systematic Review on the Risk Factors of Congenital Hypothyroidism. J. Pediatr. Rev. 2019; 7 (4) :199-210
3.Shalaby A, EL-Gazzar A. The Frequency, Types and Risk Factors of Congenital Anomalies in a Tertiary Neonatal Intensive Care Unit (A hospital based study). Annals of Neonatology Journal. 2021; 3(1):24-45.
4.Ajao A.E, Adeoye I.A. Prevalence, risk factors and outcome of congenital anomalies among neonatal admissions in OGBOMOSO, Nigeria. BMC Pediatr. 2019;19. 88. https://doi.org/10.1186/s12887-019-1471-1 4.
5.Kurinczuk JJ, Hollowell J, Boyd PA, Oakley L, Brocklehurst P, Gary R. The contribution of congenital anomalies to infant mortality. Oxford: National Prenatal Epidemiology Unit, University of Oxford; 2010.2-3.
6.Mezawa H, Tomotaki A, Yamamoto-Hanada K, Ishitsuka K, Ayabe T, Konishi M, et al. Prevalence of congenital anomalies in the Japan Environment and Children’s Study. Journal of epidemiology. 2019;29(7):247-56.
7.Eke CB, Uche EO, Chinawa JM, Obi IE, Obu HA, Ibekwe RC. Epidemiology of congenital anomalies of the central nervous system in children in Enugu, Nigeria: a retrospective study. Ann African Med. 2016;15(3):126.
8.Rabaninia T, Amjadi N. Genetic disorders in the fetus from diagnosis to treatment. World J Peri Neonatol. 2018;1(1):36-47.
9.Abbasi M, Shamsi Gooshki E, Allahbedashti N. Abortion in Iranian legal system: a review. Iran J Allergy Asthma and Immunol. 2014;13(1):71-84. [Persian]
10.Figo committee for ethical aspects of human reproduction and women's health. Ethical issues in the management of severe congenital anomalies. Int J Gynecol Obstet 2013.3(120):307-8.
11.Nasab ZA, Aminshokravi F, Moodi M, Eghbali B, Fatemimogadam F. Demographical condition of neonates with congenital abnormalities under Birjand city health centers during 2007-2012. J Birjand Univ Med Sci. 2014;21(01).[Persian]
12.Vatankhah S, Jalilvand M, Sarkhosh S, Azarmi M, Mohseni M. Prevalence of congenital anomalies in Iran: A review article. Iran J Public Health. 2017;46(6):733. (Persian)
13.Mohammadi P. Teratogenic Effects of Some Factors on the Human Fetus: A Review study. J Military Med. 2017;19(5):423-31.(Persian)
14.Irani M, Khadivzadeh T, Asghari Nekah SM, Ebrahimipour H, Tara F. The prevalence of congenital anomalies in Iran: A Systematic Review and Meta-analysis. Iran J Obstet Gynecol Infertil. 2018;21(Supple):29-41. (Persian)
15.shavogi JD, Ailes EC, Lind JN, Anderka M, Feldkamp ML, Werler MM, et al. Risk comparison for prenatal use of analgesics and selected birth defects, National Birth Defects Prevention Study 1997–2011. Ann Epid. 2017;27(10):645-53.
16.Tomatir AG, Demirhan H, Sorkun HC, Koksal A, Ozerdem F, Cilengir N. Major congenital anomalies: a five year retrospective regional study in turkey. Genet Mol Res. 2009;8(1):19-27
17.Sunitha E, Prasoona K R, Kumari T M, Srinadh B, Deepika M L N, Aruna R, Jyothy A. Risk factors for congenital anomalies in high risk pregnant women: A large study from South India, Egyptian Journal of Medical Human Genetics, 2017;18(1): 79-85. Available from:https://doi.org/10.1016/j.ejmhg.2016.04.001.
18.Ghimire LV, Croce N. Socioeconomic and racial disparities in the risk of congenital anomalies in infants of diabetic mothers: A national population-based study. Early Hum Develop. 2020; 21:105195.
19.Vrijheid M, Dolk H, Stone D, Abramsky L, Alberman E, Scott JE. Socioeconomic inequalities in risk of congenital anomaly. Arch Dis Child. 2000;82(5):349-52.
20.Mosayebi Z, Movahedian AH. Pattern of congenital malformations in consanguineous versus nonconsanguineous marriages in Kashan, Islamic Republic of Iran. Eastern Mediterranean Health J. 2007;13(4):868-75.
21.Sarkar S, Patra C, Dasgupta MK, Nayek K, Karmakar PR. Prevalence of congenital anomalies in neonates and associated risk factors in a tertiary care hospital in eastern India. J Clin Neonatol. 2013;2(3):131.
22.Francine R, Pascale S, Alineia H. Congenital anomalies: prevalence and risk factors. Univ J Public Health. 2014;2(2):58-63.
23.Costa CM, Gama SG, Leal MD. Congenital malformations in Rio de Janeiro, Brazil: prevalence and associated factors. Cadernos Saude Pub. 2006; 22(11):2423-31.
24.Hussain S, Asghar I, Sabir MU, Chattha MN, Tarar SH, Mushtaq R. Prevalence and pattern of congenital malformations among neonates in the neonatal unit of a teaching hospital. J Pak Med Assoc. 2014;64(6):629-34.
25.Mashuda F, Zuechner A, Chalya PL, Kidenya BR, Manyama M. Pattern and factors associated with congenital anomalies among young infants admitted at Bugando medical Centre, Mwanza, Tanzania. BMC Res Notes. 2014;7(1):195.
26.Vatankhah S, Jalilvand M, Sarkhosh S, Azarmi M, Mohseni M. Prevalence of congenital anomalies in Iran: A review article. Iran J Public Health. 2017;46(6):733. [Persian]
27.Liu Y, Chen S, Zühlke L, Black GC, Choy MK, Li N, et al. Global birth prevalence of congenital heart defects 1970-2017: updated systematic review and meta-analysis of 260 studies. Int J Epidemiol. 2019;48(2):455-63.
28.Wu X, Long E, Lin H, Liu Y. Prevalence and epidemiological characteristics of congenital cataract: a systematic review and meta-analysis. Sci Rep. 2016;6:28564.
Vahide Khadem Sameni (MPH)1, Fatemeh Ebrahimi (M.Sc.)2, Hassan Ahmadinia(Ph.D.)3, Seyed Zia Tabatabei (Ph.D.)4
1.MPH, Health Care Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2.MSc, Health Care Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
3.Assistant Professor, Department of Social Medicine, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
4.Corresponding Author : Assistant Professor, Department of Social Medicine, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Abstract
Introduction: Congenital anomalies are one of the important causes of disability and infant mortality. These abnormalities occur during egg fertilization or embryonic development, which can be detected by laboratory methods. The aim of this study is to investigate the prevalence of congenital anomalies in Rafsanjan City.
Methods: This cross-sectional study was performed on 4868 infants born in Rafsanjan city in 2018. Data collection tool was a questionnaire including information about mothers and infants. The questionnaire was completed using health records available in health centers of Rafsanjan city. Data were analyzed using SPSS 20 and independent t-test and Chi-square.
Results: The results showed that the overall prevalence of congenital anomalies in Rafsanjan was 5/38 per 1000 live births. Out of 4868 pregnant women, 474 (9/7%), had abortions or stillbirths before the second trimester, and 12 (0/2%) had therapeutic abortions. After analyzing these anomalies, three cases of Down syndrome (trisomy 21), three cases of Edward syndrome (trisomy 18), one case of aneuploidy, and two cases of microcephaly were found, and the rest had one of the structural abnormalities..
Conclusion: The results of this study indicated a high rate of congenital anomalies in Rafsanjan. Therefore, further studies are recommended to better understand the causes and prevent these anomalies.
Keywords: Congenital Abnormalities, Prevalence, Pregnant Women
References
1.Moezzi M, Malekpour A, pourheidar B, Mohammadkhani S. Evaluating Frequency and Risk Factors of Congenital Anomalies in Under 15 Disabled Children, Registered in Shahrekord Welfare Organization-2018. Iranian Journal of Pediatric Nursing (JPEN). 2020(6);4:47-58
2.Hashemipour M, Samei P, Kelishadi R, Hovsepian S, Hani Tabaei Zavareh N. A Systematic Review on the Risk Factors of Congenital Hypothyroidism. J. Pediatr. Rev. 2019; 7 (4) :199-210
3.Shalaby A, EL-Gazzar A. The Frequency, Types and Risk Factors of Congenital Anomalies in a Tertiary Neonatal Intensive Care Unit (A hospital based study). Annals of Neonatology Journal. 2021; 3(1):24-45.
4.Ajao A.E, Adeoye I.A. Prevalence, risk factors and outcome of congenital anomalies among neonatal admissions in OGBOMOSO, Nigeria. BMC Pediatr. 2019;19. 88. https://doi.org/10.1186/s12887-019-1471-1 4.
5.Kurinczuk JJ, Hollowell J, Boyd PA, Oakley L, Brocklehurst P, Gary R. The contribution of congenital anomalies to infant mortality. Oxford: National Prenatal Epidemiology Unit, University of Oxford; 2010.2-3.
6.Mezawa H, Tomotaki A, Yamamoto-Hanada K, Ishitsuka K, Ayabe T, Konishi M, et al. Prevalence of congenital anomalies in the Japan Environment and Children’s Study. Journal of epidemiology. 2019;29(7):247-56.
7.Eke CB, Uche EO, Chinawa JM, Obi IE, Obu HA, Ibekwe RC. Epidemiology of congenital anomalies of the central nervous system in children in Enugu, Nigeria: a retrospective study. Ann African Med. 2016;15(3):126.
8.Rabaninia T, Amjadi N. Genetic disorders in the fetus from diagnosis to treatment. World J Peri Neonatol. 2018;1(1):36-47.
9.Abbasi M, Shamsi Gooshki E, Allahbedashti N. Abortion in Iranian legal system: a review. Iran J Allergy Asthma and Immunol. 2014;13(1):71-84. [Persian]
10.Figo committee for ethical aspects of human reproduction and women's health. Ethical issues in the management of severe congenital anomalies. Int J Gynecol Obstet 2013.3(120):307-8.
11.Nasab ZA, Aminshokravi F, Moodi M, Eghbali B, Fatemimogadam F. Demographical condition of neonates with congenital abnormalities under Birjand city health centers during 2007-2012. J Birjand Univ Med Sci. 2014;21(01).[Persian]
12.Vatankhah S, Jalilvand M, Sarkhosh S, Azarmi M, Mohseni M. Prevalence of congenital anomalies in Iran: A review article. Iran J Public Health. 2017;46(6):733. (Persian)
13.Mohammadi P. Teratogenic Effects of Some Factors on the Human Fetus: A Review study. J Military Med. 2017;19(5):423-31.(Persian)
14.Irani M, Khadivzadeh T, Asghari Nekah SM, Ebrahimipour H, Tara F. The prevalence of congenital anomalies in Iran: A Systematic Review and Meta-analysis. Iran J Obstet Gynecol Infertil. 2018;21(Supple):29-41. (Persian)
15.shavogi JD, Ailes EC, Lind JN, Anderka M, Feldkamp ML, Werler MM, et al. Risk comparison for prenatal use of analgesics and selected birth defects, National Birth Defects Prevention Study 1997–2011. Ann Epid. 2017;27(10):645-53.
16.Tomatir AG, Demirhan H, Sorkun HC, Koksal A, Ozerdem F, Cilengir N. Major congenital anomalies: a five year retrospective regional study in turkey. Genet Mol Res. 2009;8(1):19-27
17.Sunitha E, Prasoona K R, Kumari T M, Srinadh B, Deepika M L N, Aruna R, Jyothy A. Risk factors for congenital anomalies in high risk pregnant women: A large study from South India, Egyptian Journal of Medical Human Genetics, 2017;18(1): 79-85. Available from:https://doi.org/10.1016/j.ejmhg.2016.04.001.
18.Ghimire LV, Croce N. Socioeconomic and racial disparities in the risk of congenital anomalies in infants of diabetic mothers: A national population-based study. Early Hum Develop. 2020; 21:105195.
19.Vrijheid M, Dolk H, Stone D, Abramsky L, Alberman E, Scott JE. Socioeconomic inequalities in risk of congenital anomaly. Arch Dis Child. 2000;82(5):349-52.
20.Mosayebi Z, Movahedian AH. Pattern of congenital malformations in consanguineous versus nonconsanguineous marriages in Kashan, Islamic Republic of Iran. Eastern Mediterranean Health J. 2007;13(4):868-75.
21.Sarkar S, Patra C, Dasgupta MK, Nayek K, Karmakar PR. Prevalence of congenital anomalies in neonates and associated risk factors in a tertiary care hospital in eastern India. J Clin Neonatol. 2013;2(3):131.
22.Francine R, Pascale S, Alineia H. Congenital anomalies: prevalence and risk factors. Univ J Public Health. 2014;2(2):58-63.
23.Costa CM, Gama SG, Leal MD. Congenital malformations in Rio de Janeiro, Brazil: prevalence and associated factors. Cadernos Saude Pub. 2006; 22(11):2423-31.
24.Hussain S, Asghar I, Sabir MU, Chattha MN, Tarar SH, Mushtaq R. Prevalence and pattern of congenital malformations among neonates in the neonatal unit of a teaching hospital. J Pak Med Assoc. 2014;64(6):629-34.
25.Mashuda F, Zuechner A, Chalya PL, Kidenya BR, Manyama M. Pattern and factors associated with congenital anomalies among young infants admitted at Bugando medical Centre, Mwanza, Tanzania. BMC Res Notes. 2014;7(1):195.
26.Vatankhah S, Jalilvand M, Sarkhosh S, Azarmi M, Mohseni M. Prevalence of congenital anomalies in Iran: A review article. Iran J Public Health. 2017;46(6):733. [Persian]
27.Liu Y, Chen S, Zühlke L, Black GC, Choy MK, Li N, et al. Global birth prevalence of congenital heart defects 1970-2017: updated systematic review and meta-analysis of 260 studies. Int J Epidemiol. 2019;48(2):455-63.
28.Wu X, Long E, Lin H, Liu Y. Prevalence and epidemiological characteristics of congenital cataract: a systematic review and meta-analysis. Sci Rep. 2016;6:28564.
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Received: 2022/10/22 | Accepted: 2023/03/5 | Published: 2023/07/22
Received: 2022/10/22 | Accepted: 2023/03/5 | Published: 2023/07/22
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