The Journal of

Background: Diabetes is one of the major causes of mortality and its prevalence is increasing around the world. It is widely accepted that diabetes is an oxidative disease. One of the antioxidants used in oxidative diseases is CoQ10.The aim of this study is to find out the effect of CoQ10 on insulin resistance and glycaemic control of patients with type two diabetes. Method: This is a double blind randomized controlled clinical trial which was held on 70 type 2 diabetic patients in Yazd Diabetes Research Center in 2011.The diabetic patients were randomly divided into two groups, CoQ10 and placebo. The Two groups took two capsules containing 100mg CoQ10 or placebo every day for 12 weeks. Blood glucose and insulin resistance were measured before and after the trial. Results: sixty two patients completed the trial. There was no significant difference between the mean of fasting blood glucose, median insulin and median secretion of the beta cells between two groups after the trial. The mean difference of Insulin sensitivity change was significantly greater in CoQ10 group (12.1+67.1vs -19.1+50.1: P<0.05).The median difference of HOMA (insulin resistance) between two groups after the trial was significant (P<0.05). Conclusion: This study revealed that CoQ10 supplementation significantly increases insulin sensitivity and decreases insulin resistance in type 2 diabetes. Regarding to the results of this study and other reports, supplementation with CoQ10 can be recommended for diabetic patients.