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Introduction: Toxoplasmosis is a zoonotic disease distributed worldwide. Early infection by these protozoa can develop an antibody response which is preventive of abortion and congenital Toxoplasmosis in pregnant women. This study was conducted to determine Seroprevalence of Toxoplasmosis in women referring to Kashan Reference Laboratory. Methods: This descriptive study was carried out in 2008-2012. Blood samples of 434 women referring to Reference laboratory were examined for IgG and IgM antibody of Toxoplasmosis by Elisa method. Results: Out of 434 women, 311 (71.66%) were seronegative, 123 (28.34%) had IgG antibody (≥10 IU/ML), and 7 (1.6%) cases were positive for IgM antibody spontaneously (>=1.1 IU/ML).The highest seropsitive rate was identified in 25-35 year-oldgroup (46.3%) and 35-45 year-old group (26%) respectively. In 36.6% of seropsitive women, a 10-50 IU/ML of IgG antibody was detected and only 5 subjects(4.1%) enjoyed up to 250 IU/ML antibody. Conclusion: This study showed that a high rate (71.66%) of women who had referred to Kashan Reference Laboratory were negative for Toxoplasmosis antibody. This is very important for the reason that many of the pregnant women are susceptible and thus exposed to Toxoplasmosisis. So preventive and educational measures are recommended for women in this region.

Keywords: Toxoplasmosis, Women, Elisa, Kashan

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