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بررسی محتوای التهابی رژیم غذایی بیماران مبتلا به سرطان معده مراجعه کننده به مرکز جامع سرطان مازندران، یک مطالعه مورد-شاهدی
Investigating The Inflammatory Content of The Diet of Gastric Cancer Patients Referred to Mazandaran Comprehensive Cancer Center, a Case-Control Study
تغذیه
Nutrition
پژوهشي
Research
<span style="font-size:12pt"><span style="background:white"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span b="" style="font-family:" zar=""><span style="color:black">مقدمه:</span></span></b><span b="" style="font-family:" zar=""><span style="color:black"> سرطان معده یکی از شایعترین سرطانها در ایران و جهان است که نقش عوامل تغذیهای در بروز و پیشرفت آن، مورد توجه پژوهشگران قرار دارد. پتانسیل التهابی رژیم غذایی به عنوان عامل خطر در ایجاد بعضی بدخیمی ها معرفی شده است. هدف بررسی حاضر سنجش پتانسیل التهابی رژیم غذایی بیماران و مقایسه با گروه شاهد بوده است.</span></span><span dir="LTR" style="color:black"></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="background:white"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span b="" style="font-family:" zar=""><span style="color:black">روش بررسی:</span></span></b> <span b="" style="font-family:" zar=""><span style="color:black">این مطالعه ی مورد-شاهدی در سال 1401 بر 80 بیمار مبتلا به سرطان معده با تایید پاتولوژی مراجعه کننده به مرکز سرطان بیمارستان امام خمینی (ره) ساری و 79 شاهد از داوطلبان سالم، بدون علائم گوارشی و سابقه قبلی سرطان انجام شد. پرسشنامه بسامد </span></span><span b="" style="font-family:" zar=""><span style="color:black">مصرف </span></span><span b="" style="font-family:" zar=""><span style="color:black">خوراک مطالعه کوهورت </span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">PERISAN</span></span><span b="" style="font-family:" zar=""><span style="color:black"> به منظور ثبت فراوانی و انوع مواد غذایی مصرفی استفاده شد. ثبت و تجزیه تحلیل آماری با نرم افزار</span></span> <span dir="LTR" style="font-size:11.0pt"><span style="color:black">SPSS</span></span><span b="" style="font-family:" zar=""><span style="color:black">نسخه 21 و آزمون های آماری </span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">T test</span></span><b><span lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" zar=""><span style="color:black">، </span></span></span></b><span lang="AR-SA" style="font-size:11.0pt"><span b="" style="font-family:" zar=""><span style="color:black">من ویتنی</span></span></span> <span b="" style="font-family:" zar=""><span style="color:black">و کای دو</span></span><span b="" style="font-family:" zar=""><span style="color:black"> با در نظر گرفتن </span></span> <span lang="FA" style="font-size:11.0pt"><span b="" style="font-family:" zar=""><span style="color:black">05/0</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">P</span></span><b><span dir="LTR" style="font-size:11.0pt"><span style="color:black"><</span></span></b> <span b="" style="font-family:" zar=""><span style="color:black">صورت گرفت</span></span><span dir="LTR" style="color:black">.</span><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="background:white"><span style="page-break-after:avoid"><span style="tab-stops:right 6.0in"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">یافته ها:</span></span></span></b><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt"> مصرف گوشت قرمز (</span></span></span><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">054/0</span></span><span dir="LTR" lang="EN-GB" style="font-size:11.0pt"><span style="letter-spacing:-.1pt">P</span></span><span dir="LTR" lang="EN-GB" style="letter-spacing:-.1pt">=</span><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">)، امعا و احشا </span></span></span><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">(</span></span></span><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">013/0</span></span><span dir="LTR" style="font-size:11.0pt"><span style="letter-spacing:-.1pt">P</span></span><span dir="LTR" style="font-size:11.0pt"><span style="letter-spacing:-.1pt">=</span></span><b><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">)</span></span></span></b> <span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">و همچنین محصولات گوجه فرنگی </span></span></span><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">(</span></span></span><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">00/0</span></span><span dir="LTR" style="font-size:11.0pt"><span style="letter-spacing:-.1pt">P</span></span><b><span dir="LTR" style="letter-spacing:-.1pt">=</span></b><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">) </span></span></span><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">در گروه شاهد بیشتر بود. در دسته بندی مواد غذایی ضد التهابی، سبزیجات برگ زرد به میزان بیشتری توسط افراد شاهد مصرف می شدند(</span></span></span><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">003/0</span></span><span dir="LTR" style="font-size:11.0pt"><span style="letter-spacing:-.1pt">P</span></span><span dir="LTR" style="letter-spacing:-.1pt">=</span><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">).</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="background:white"><span style="page-break-after:avoid"><span style="tab-stops:right 6.0in"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">نتیجه گیری:</span></span></span></b><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt"> نتایج مطالعه ارتباط معنی</span></span></span> <span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">داری </span></span></span><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">بین</span></span></span><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt"> مصرف گوشت قرمز و ریسک سرطان معده نشان نداد، اما مصرف بیشتر سبزیجات ممکن است نقش محافظتی داشته باشد. این یافته ها حاکی از اهمیت افزایش مصرف سبزیجات در پیشگیری از سرطان معده است. به دلیل محدودیت های روش شناسی، مطالعات آینده نگر برای تایید نتایج ضروری است.</span></span></span><span dir="LTR" lang="EN-GB" style="color:black"><span style="letter-spacing:-.1pt"></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="background:white"><span style="tab-stops:102.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span b="" style="font-family:" zar=""> </span></span></span></span></span></span></span><br>
<div aria-label="شکستن صفحه" class="cke_pagebreak" data-cke-display-name="pagebreak" data-cke-pagebreak="1" style="page-break-after:always" title="شکستن صفحه" contenteditable="false"></div>
<span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt"><span style="color:#0d0d0d">Introduction:</span></span></b> <span style="font-size:11.0pt">Gastric cancer is one of the most common cancers in Iran and worldwide, and the role of dietary factors in its incidence and progression has attracted researchers' attention. The inflammatory potential of the diet has been introduced as a risk factor in the development of certain malignancies. The present study aimed to assess the inflammatory potential of the diet in gastric cancer patients and compare it with a control group.</span><span style="font-size:11.0pt"><span style="color:#0d0d0d"></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt"><span style="color:#0d0d0d">Methods:</span></span></b> <span style="font-size:11.0pt">This case-control study was conducted in 2022 on 80 pathologically confirmed gastric cancer patients referred to the Imam Khomeini Cancer Center, Sari, and 79 controls who were healthy volunteers without gastrointestinal symptoms or a previous history of cancer. The PERISAN cohort food frequency questionnaire (FFQ) was used to record the frequency and types of consumed foods. Data collection and statistical analysis were performed using SPSS version 21. Statistical tests including the T-test and Chi-square test were applied with a significance level of P< 0/05.</span><span style="font-size:11.0pt"><span style="color:#0d0d0d"></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt"><span style="color:#0d0d0d">Results:</span></span></b> <span style="font-size:11.0pt">The consumption of red meat (P=0/054), organ meat (P=0/013), and tomato products (P=0/000) were higher in the control group. In the category of anti-inflammatory foods, yellow leafy vegetables were consumed significantly more by the control group (P=0/003).</span><span style="font-size:11.0pt"><span style="color:#0d0d0d"></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt"><span style="color:#0d0d0d">Conclusion:</span></span></b> <span style="font-size:11.0pt">The study results showed no significant association between red meat consumption and the risk of gastric cancer; however, higher vegetable intake may have a protective role. These findings highlight the importance of increasing vegetable consumption for gastric cancer prevention. Due to methodological limitations, prospective studies are necessary to confirm these results.</span><span style="font-size:11.0pt"><span style="color:#0d0d0d"></span></span></span></span></span><br>
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شاخص التهاب غذایی, سرطان معده, عوامل خطر
Food, Inflammation, Stomach Neoplasms, Risk Factors.
88
99
http://tbj.ssu.ac.ir/browse.php?a_code=A-10-3253-1&slc_lang=fa&sid=1
Mina
Motevalli
مینا
متولی
mina1991motevalli@yahoo.com