Background: Human has encountered lots of pathogen and non-pathogenic agents all over the history and has used lots of methods for the control and treatment of such diseases. Apitherapy is one of such measures.

 Method: This article is a review one. The related investigations were searched from websites and reliable

 published texts. Different databases were explored based on appropriate key words.

 Results: Historically, using honey bee and its products for treating several diseases is reflected to human recognition from this useful insect. Several honey bee products including honey, sting, pollen, royal jelly, propels, and wax are products that have used for treating different diseases such as allergy, blood diseases, pulmonary and nervous disease, diabetics, audit, eye, immunosuppressive diseases, cancer, psychiatric, dermatosis, and virus and giardia borne diseases, shagas and malaria.

 Conclusion: This review article will introduce some new products of honey bee in control and treatment of different disease both in Iran and all over the world.