Introduction: Contraceptive Pills Are Accepted Around the World. Since the Introduction of the Pillstheir Use Increases the Risk of Venous and Arterial Complications, but There Are Doubtson Whether Low-Dose (LD) Estrogen Pills Could be a Risk factor. This Study Aimed to Examine the Lipid Profile in Women Exposed to (LD) Oral Contraceptives Compared to Unexposed Women.

Materials and methods: In This Mix Cohort, 100 Women Aged 20-35 Years Old Referring to Health Care Centers in Yazd, Iran Were Conducted Through Face to Face Interviews by the Researcher Who Asked for Demographic and Anthropometric Characteristics and Also Took Blood Samples for Measurement of Lipid Profile. The Data Were Analyzed using SPSS Version 21 and Chi-Square Test as Well as T-test.

Results: In the Exposed Group Total Cholesterol (180/7 ± 38/28 mg dl^-1), Triglycerides (129/82 ± 47/92 mg dl^-1), LDL (101/42 ± 30/66 mg dl^-1) Were Significantly Higher than the Unexposed Group (Total Cholesterol 159 ± 30/26 mg dl^-1, Triglycerides 93/60 ± 44/01 mg dl^-1 and LDL 84/84±24/70 mg dl^-1).  However, HDLof the Exposed Group (56/46 ± 8/42 mg dl^-1) Did not Showa Significant Differencein Comparison to the Unexposed Group (56/18 ± 8/91 mg dl^-1 ).

 Conclusion  : LD Pills Increase Levels of Cholesterol, Triglycerides and LDL, so Taking these Pills may Cause Dyslipidemia.