Introduction: Obesity leads to an increase in oxidative stress and insulin resistance.Flaxseed consumption is increasingly incorporated into the diet of individuals, in purpose of weight reduction.There are limited data on efficacy of flaxseed on improving anthropometric indices.The purpose of this study was to assess the effects of flaxseed on anthropometric and oxidative stress indexes in overweight and obese prediabeticindividuals.

Methods: This study was conducted among 99prediabeticparticipants with body mass index(BMI)25-34.9.They are assigned randomly to three groups:high dose flaxseed(HD) and low dose flaxseed(LD) as intervention groups and third group as control group(C).HD receiveddaily 40 g milled flaxseed,LD receiveddaily 20 g flaxseed for 12 week and C group received no intervention.Anthropometric indicesand MDAwere measured before and after intervention.

Result: 92 individuals remained at the end of 12^th week for analysis.Weight, BMI and waist circumstancesdecreased in intervention groups compared to the control group and baseline(p<0/005).Although significant differences observed in MDA in HDand C group, but this difference was not significantbetween intervention groups and control.

Conclusion: The result of present study demonstrated that consumption of both dose of flaxseed (daily 20 g and 40 g) can lower weight,BMI and waist circumstancesinprediabetic patients, but it’s not dose-dependent, but flaxseed has no significant effect on oxidative stress in prediabetes.