Volume 12, Issue 1 (6-2013)                   TB 2013, 12(1): 14-23 | Back to browse issues page


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Bagheri N, Mozaffari-Khosravi H, Najarzadeh A, Salehifar E, Fallahzadeh H. Effect of Coenzyme-Q10 Supplementation on Blood Pressure in Hypertensive Patients: A Randomized Double-Blind Clinical Trial. TB. 2013; 12 (1) :14-23
URL: http://tbj.ssu.ac.ir/article-1-454-en.html

Sadoughi University of Medical Sciences, Yazd, Iran , mozaffari.kh@gmail.com
Abstract:   (4348 Views)

  Background : Hypertension is one of the most important challenges in human health and is now the most important risk factor for cardiovascular and renal diseases . Thus, using new approaches to manage and treat this problem is important . This study aimed to determine the effect of coenzyme-Q10 supplementation on blood pressure in hypertensive patients.

  Methods : This randomized clinical trial with a three-month supplementation and participation of 60 hypertensive patients was conducted . Patients were randomly divided into two groups Placebo (PG) and Experimental EG groups. EG received a capsule containing 100 mg coenzyme Q10 daily but PG did not. S ystolic (SBP) and diastolic (DBP) blood pressure were measured before and twelve weeks after the intervention.

  Results : The median SBP before and after the intervention in SG, was 150 and 130 mmHg (P=0.002) respectively . The same figures in the PG was 150 and 147 mmHg (P=0.52), respectively. The median SBP was not significantly different between two groups before intervention , however at the end of the intervention it was significant (p=0.01). The median DBP before and after the intervention was not significantly different between the two groups, a nd also in each group before and after the intervention was not significant.

  Conclusion : This study indicates that supplementation of daily 100 mg of coenzyme Q10 during 12 weeks with conventional treatment in patients with moderate hypertension produces a significant reduction in SBP. So it can be recommend to be used it as a supplement for hypertensive patients.

Full-Text [PDF 157 kb]   (689 Downloads)    
Type of Study: Research | Subject: Special
Received: 2013/06/17 | Accepted: 2014/07/6 | Published: 2014/07/6

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