Introduction: The prevalence of job-related stress has been proved to be high within the dentists in different studies. This stress, resulted from such factors as poor lightening as well as noise of dental office, can cause emotional distress, threaten dentists’ physical health and affect their quality of life. Hence, this study aimed to evaluate dentists’ professional quality of life, job-related stress and two important workplace factors of lighting and noise.

Methods: In this analytical-descriptive and cross sectional study, the researcher visited the dental offices in Shiraz and measured lighting and noise of the places. Moreover, dentist's quality of life and job stress were determined using McGill quality of life questionnaire and job-stress questionnaire. The relationship between quantitative variables was determined using regression test and the multiple regression t est was also applied for the modeling process.

Results: The local noise mean cased by the dental drills was 75.5 and 74.5 in the public and private offices, respectively. In 2.2% of the dental offices, lightening condition was reported below the standard levels. The study results revealed that 58.9% of dentists participating in this study experienced good or fairly good quality of life.

Conclusion: The study findings suggested that workplace conditions were correlated with the dentists’ professional stress and quality of life. Training how to manage this psychological disorder can significantly reduce its destructive effects and as a result, quality of life can be increased.