Introduction: Leishmaniasis is wide range, worldwide, without drug, vaccine, secticide and has not sterile immunity and Efforts in this field has not been successful. Research on efficacy of medicinal plants, is including the research infrastructure. Herbaceous plants tomentose perennial local name Khouchoobe in Kerman And official Zangoolaei Looleh baric and scientific name Onosma stinosiphon "Traditionally in the past as a poultice to treat skin, superficial cuts, wounds and acne has been used. Its disinfectant properties at the site of the wound have been proved. Cutaneous Leishmaniasis is throughout the country as epidemics and endemic. Purpose of this is Effectiveness Comparison between Onosma. This study was to Effect of Onosma stinosiphon Extract on Cutaneous Leishmaniasis in Infected BALB/c mice. Methods: sufficient root of Onosma stinosiphon were minced and they were dissolved in Ethanol 80. Then they were placed into the stirrer with magnets in room temperature for 24 hours. Next, they were softened. This compound was, first, sterilized and prepared as tropica with concentration of 40, 60 and 80%. It was refrigerated until used. In the lab, 50 BABL/c mice were infected with the parasite Leishmania (L) tropica, They were divided into four control groups and a group that received 40, 60, and 80% concentration of the extract- Onosma stinosiphon and Honey As soon as the Leishmania lesion appeared, Extract- Onosma stinosiphon was applied every two days. As well, the foot and the size of the lesion were measured the weight was also taken in all mice in the four groups by using ale and coliss every week until the death of the last mouse in the control group. Results: Average weight of mice receiving extracts each other and an average weight of mice of receiving honey with an average weight of control mice showed no significant difference (P> 0.05). Average diameter ulcer mice receiving extracts each other and an Average diameter ulcer mice receiving honey with an average diameter size of mice control mice showed significant difference (P = 0.000). Determine the average size of the spleen (mm) and compare survival time (days) in any study group which was not significant (P> 0.05). Conclusion: topical use of Onosma stinosiphon extract in the treatment of cutaneous Leishmaniasis wounds causes to be the growth slower diameter size and use of topical honey prevention of cause necrosis and creation of secondary bacterial infections are, but it Do not none whole parasite removal from the body.

Keywords: Cutaneous Leishmaniasis, Onosma stinosiphon, BALB/c Mice, Extract.

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