Abstract Introduction: Cancers considered in Iran as the third leading cause of deaths and skin cancer is the most common that its incidence higher in Yazd province than the country. Due to the important role of teachers and schools as a place for educating students and their families this study was performed with aims to determine the effectiveness of skin cancer prevention educational program among teachers in Yazd city. Methods: This research was as a before and after study among 80 teachers of Yazd city who were selected randomly. A Valid and reliable questionnaire was used in four sections include, demographic information, knowledge, attitude and practice who was completed by self-report in two stages, before and after education. Results: Participant’s age ranged was 23-51 years with a mean age of 36.87±6.22. 77.3 percent female, 22.7 male. Mean score of knowledge, attitude and practice after educational intervention increased (P<0.001). After intervention by increased rates of participants' attitudes also practice increased (r=0.0407**, p=0.001) and men had higher attitude compared to women (p=0.04). Conclusion: Educational intervention was significantly effective on knowledge, attitude and healthy practice teachers in Yazd city about skin cancer.
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